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Nitroglycerin, a nitrate, causes smooth muscle relaxation. Nitroglycerin is indicated to relieve chest discomfort suspected to be the result of an acute myocardial infarction otherwise known in short as an AMI. Nitro should be administered sublingually in the dose of .4 mg which is usually 1 tablet. This can be repeated in 5 minute intervals to a maximum of three tablets. Nitro can also be administered via a sublingual spray, which is given with 1 spray equivalent to .4 mg in metered doses.