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When a patient has no pulse, no breathing, and shows a flat line on the ECG monitor, asystole is present. CPR needs to be initiated first. Asystole is not a shockable rhythm and treatment for Asystole involves high quality CPR, airway management, IV or IO therapy, and medication therapy which is 1mg epinephrine 1:10,000 every 3-5 minutes rapid IV or IO push. Remember, CPR should not be stopped for the delivery of medications. Unless there are special circumstances like hypothermia or drug overdose, prolonged resuscitative efforts beyond 20 minutes are usually unnecessary and futile. The team leader may consider stopping resuscitation if ETCo2 is less than 10 after 20 minutes of high quality CPR and all treatments have been exhausted.