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Amiodarone is primarily chosen for ACLS as the first-line antiarrhythmic agent for cardiac arrest because it has reliably and clinically shown effectiveness in improving the rate of return of spontaneous circulation otherwise known as ROSC. Amiodarone is a drug that can prolong AV conduction, the AV refractory period and QRS and Q-T intervals, which ultimately slows the heart rate. When using Amiodarone to treat Vfib or pulseless VTach cardiac arrest, the first dose is 300 mg IV/IO push. The second dose is delivered at 150mg IV/IO push.