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Every healthcare system should implement a comprehensive and multidisciplinary system of care in a universal and consistent manner for the treatment of post-cardiac arrest patients in order to assure the very best of outcomes. These ROSC programs should address targeted temperature management (TTM), hemodynamic and ventilation optimization, immediate coronary reperfusion with percutaneous coronary intervention (PCI) for eligible patients, neurologic care and prognostication, and other structured interventions.